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Statins may reduce cancer risk through mechanisms separate to cholesterol

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Fuente: Health News Report - View all news from this site
Statins may reduce cancer risk through mechanisms separate to cholesterol Statins may reduce cancer risk through mechanisms separate to cholesterol

Statins may reduce cancer risk through mechanisms separate to cholesterol






  Cholesterol-lowering drugs called statins may reduce cancer risk in humans through a pathway unrelated to cholesterol, says a study published today in eLife.Statins reduce levels of LDL-cholesterol, the so-called 'bad' cholesterol, by inhibiting an enzyme called HMG-CoA-reductase (HMGCR). Clinical trials have previously demonstrated convincing evidence that statins reduce the risk of heart attacks and other cardiovascular diseases. But evidence for the potential effect of statins to reduce the risk of cancer is less clear."Previous laboratory studies have suggested that lipids including cholesterol play a role in the development of cancer, and that statins inhibit cancer development," explains lead author Paul Carter, Cardiology Academic Clinical Fellow at the Department of Health and Primary Care, University of Cambridge, UK. "However, no trials have been designed to assess the role of statins for cancer prevention in clinical practice. We decided to assess the potential effect of statin therapy on cancer risk using evidence from human genetics."To do this, Carter and the team studied genetic variants that mimic the effect of statins using a technique known as Mendelian randomization in UK Biobank, a large study of UK residents that tracks the diagnosis and treatment of many serious illnesses. Mendelian randomization assesses associations between genetically predicted levels of a risk factor and a disease outcome, in order to predict t...
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Statins may reduce cancer risk through mechanisms separate to cholesterol Statins may reduce cancer risk through mechanisms separate to cholesterol

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News source: Health News Report
Publication date: 16-10-2020 16:06
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